Bioavailability of vitamin D photoisomers from UVB-exposed button mushrooms

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00030947

Enrollment

Registered

2022-12-16

Start date

2023-02-09

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The study investigates whether vitamin D photoisomers, that are formed in UVB-treated foods, can be absorbed and metabolized in healthy volunteers

Interventions

Group 1: Intervention group: received UVB-exposed button mushrooms Group 2: Control group: received non-UVB-exposed button mushrooms

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: healthy subjects Age between 18 and 65 years Body Mass Index in the range of 18.5 to 29.9 kg/m2

Exclusion criteria

Exclusion criteria: Acute or chronic illnesses (high blood pressure, heart disease, diabetes, kidney disease, liver disease, alcohol dependence, etc.) - Taking medication (except oral contraceptives) - Pregnancy or breastfeeding - Food intolerances or allergies to mushrooms and dairy products - Smokers - Visits to solariums or previous holidays in southern countries or in the Alps or other high mountains - Participation in another study - Blood donation during the last 2 months before the start of the study - Dieting - Severe weight loss or weight loss (= 3 kg) within the last month

Design outcomes

Primary

Measure	Time frame
Plasma concentrations of vitamin D photoisomers (such as lumisterol, tachysterol and corresponding hydroxyderivates) after the consumption of the UVB-exposed button mushrooms versus non-UVB-exposed button mushrooms	—

Secondary

Measure	Time frame
Plasma concentrations of: Vitamin D metabolites (vitamin D2, vitamin D3, 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D2, calcitriol, ergosterol). Calcium, inorganic phosphate, parathyroid hormone, fibroblast growth factor-23 Lipids (cholesterol, triglycerides) Inflammation markers (CRP, Interleukin-6) Lumi- and tachysterol in winter versus summer Relative mRNA and protein expression in isolated peripheral blood mononuclear cells (PBMC): Cytochrome P450 enzymes Target genes of transcription factors	—

Measure

Time frame

Plasma concentrations of: Vitamin D metabolites (vitamin D2, vitamin D3, 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, 24,25-dihydroxyvitamin D2, calcitriol, ergosterol). Calcium, inorganic phosphate, parathyroid hormone, fibroblast growth factor-23 Lipids (cholesterol, triglycerides) Inflammation markers (CRP, Interleukin-6) Lumi- and tachysterol in winter versus summer Relative mRNA and protein expression in isolated peripheral blood mononuclear cells (PBMC): Cytochrome P450 enzymes Target genes of transcription factors

—

Countries

Germany

Contacts

Public ContactGabriele Stangl

Martin-Luther-Universität Halle-Wittenberg

gabriele.stangl@landw.uni-halle.de+493455522707

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026