In search for potential candidates of the "hepatic factor" in patients with univentricular heart defects at different stages of palliation with and without intrapulmonary arteriovenous malformations using proteomics and olink

In search for potential candidates of the "hepatic factor" in patients with univentricular heart defects at different stages of palliation with and without intrapulmonary arteriovenous malformations using proteomics and olink - In Search for the Hepatic Factor

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00030944

Enrollment

Registered

2023-02-09

Start date

2022-11-01

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary arteriovenous malformations in patients with univentricular physiology

Interventions

Group 1: Single-arm trial: 40 single ventricle patients and 10 patients with biventricular hearts, receiving routine cardiac catheterization with already planned oximetry. One sample each of (1) rich

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: - 40 single ventricle patients receiving routine cardiac catheterization with already planned oximetry - 10 patients with biventricular hearts, receiving routine cardiac catheterization with already planned oximetry

Exclusion criteria

Exclusion criteria: - Refusal to participate in the study - anaemia with haemoglobin < 10.0 mg/dl in the routinely performed blood gas analyses

Design outcomes

Primary

Measure	Time frame
The primary endpoints are the results of protein analysis comparing hepatic vein blood to blood without hepatic vein blood, leading to a potential hepatic factor.	—

Secondary

Measure	Time frame
Secondary endpoints are - formation/extent of pulmonary arteriovenous malformation - clinical signs of cyanosis and heart failure (oxygen saturation, physical capacity)	—

Countries

Germany

Contacts

Public ContactMarie Schafstedde

Deutsches Herzzentrum Charité

schafstedde@dhzb.de0049-17621237258

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026