I25 T98
Conditions
Interventions
Group 1: Patients undergoing elective bypass surgery using extracorporeal circulation who require perioperative antibiotic prophylaxis.
Group 2: Patients undergoing elective bypass surgery without the
Sponsors
Universitätsklinikum Augsburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Patients undergoing elective bypass surgery who require perioperative antibiotic prophylaxis - Written declaration of consent by the patient
Exclusion criteria
Exclusion criteria: - Patients who have received therapy with cefuroxime in the 72 hours prior to surgery. - Known allergic reaction, hypersensitivity or contraindication to cefuroxime or other ß-lactam antibiotics (e.g. penicillins, cephalosporins). - Severe renal insufficiency < 20 ml/min/1.73 m2 - Non-guideline discontinuation of blood thinning medications Medications if urgency does not allow the surgery to be postponed for the appropriate number of days. - Active participation in other interventional studies according to AMG or MPDG - Women during pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the concentration-time curve (AUC 0-8) of cefuroxime in interstitial fluid and plasma | — |
Secondary
| Measure | Time frame |
|---|---|
| Pharmacokinetic parameters: - Area under the concentration-time curve (AUC). - maximum concentrations (Cmax), - Cmax/MIC (MIC = minimal inhibitory concentration) - AUC/MIC in interstitial fluid and plasma after drug application, - time over MIC (T>MIC) - AUCtissue/AUCplasma ratio, - PK/PD parameters, - half-lives (t1/2); Incidence of wound infections - Influence of ECC on AUC and other pharmacokinetic parameters. | — |
Countries
Germany
Contacts
Public ContactPhilipp Simon
Universitätsklinikum Augsburg
Outcome results
None listed