J80 U07.1
Conditions
Interventions
Group 1: Ventilated patients with mild, moderate or severe acute respiratory distress syndrome (ARDS) due to SARS-CoV-2 virus infection with PEEP-titration by EIT RVDi measuring.
Group 2: Ventilated p
Sponsors
Universitätsklinikum Augsburg
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. ARDS as defined by Berlin meet the following criteria (all): a. Sudden onset b. Bilateral infiltrates in chest x-ray or CT chest c. PaO2/FiO2 < 300 d. No clinical evidence of cardiac cause of respiratory failure 2. need for intubation and invasive ventilation 3. written informed consent
Exclusion criteria
Exclusion criteria: 1. age < 18 years 2. known pulmonary fibrosis/restrictive ventilation disorder 3. severe emphysema 4. pregnancy and breastfeeding 5. severe cardiac disease (New York Heart Association classification III or IV, acute ischaemic event, persistent ventricular arrhythmia) 6. pre-existing neuromuscular disease 7. implanted pacemaker or ICD 8. participation in other interventional studies within the last three months 9. severity of illness that makes death within the next 24 h highly probable in the investigator's opinion 10. DNR/DNI order
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PaO2/FiO2 one hour after setting PEEP in each group | — |
Secondary
| Measure | Time frame |
|---|---|
| Adjusted PEEP Barotrauma Haemodynamic instability Description of ventilation distribution in early ARDS Effects of PEEP determination on ventilation distribution Correlation of physiological parameters of lung function with the results of quantitative CT analysis Histological degree of lung damage (if autopsy is performed) | — |
Countries
Germany
Contacts
Public ContactPhilipp Simon
Universitätsklinikum Augsburg
Outcome results
None listed