Patients with initial diagnosis of cancer (breast cancer) prior to outpatient anthracycline therapy C50
Conditions
Interventions
Group 1: Supervised high-intensity interval training for 8 weeks concurrent with medical therapy
Group 2: Standard care (control arm): Consists of currently existing physical therapy recommendations a
Sponsors
Uniklinik Köln
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Patients (= 18 years) with initial diagnosis of cancer (breast cancer). - Indication for anthracycline therapy - Prior to initiation of medical therapy (max. 2 weeks after diagnosis). - Life expectancy =18 months - Written and valid informed consent from the patient.
Exclusion criteria
Exclusion criteria: - Contraindications to exercise therapy interventions and all disease situations that do not allow exercise, in particular: - previous myocardial infarction or CABG - angina pectoris - EF 80 years - BMI > 30 or > 150 kg body weight
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiovascular health - echocardiography (LVEF, Strain), ECG (QT-Time), endothelial measurement (retina, upper arm), Biomarker (Troponin-T, NT-pro-BNP) | — |
Secondary
| Measure | Time frame |
|---|---|
| feasibility - implementation (organisation, time), aherence, practicability, content effective trends - movement behavior, cardiorespiratory fitness, cardiovascular riskprofile (SCORE-riskdiagram) | — |
Countries
Germany
Contacts
Public ContactNora Zoth
Uniklinik Köln
Outcome results
None listed