The effect of Osteopathic Manual Therapy compared with shame tratment on the autonomic nervous system, measured by heart rate variability, in long/post COVID-19 patiens with fatigue syndrome. A clinical randomised controlled trial.

The effect of Osteopathic Manual Therapy compared with shame tratment on the autonomic nervous system, measured by heart rate variability, in long/post COVID-19 patiens with fatigue syndrome. A clinical randomised controlled trial. - COVIDOst

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00030829

Enrollment

Registered

2023-06-12

Start date

2023-05-11

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Long/Poast Covid-19 condition G93.3 U09.9

Interventions

Group 1: Osteopathic manual treatment in long/post COVID-19 patients with Fatigue syndrome Group 2: Sham treatment in long/post COVID-19 patients with Fatigue syndrome

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - COVID 19 patients, post-acute phase longer than 4 weeks after acute infection with SARS-CoV-2 and with signs of fatigue syndrome. - Confirmation by Fatigue Assessment Scale (FAS) with 22 points or more. - The subject should not have had osteopathic treatment. - Signed informed consent form

Exclusion criteria

Exclusion criteria: - Alcohol abuse and other drug abuse - Pregnancy in the first trimester

Design outcomes

Primary

Measure	Time frame
The measurement parameters of heart rate variability RMSSD, pNN50, TP, SDNN, LF, HF, LF/HF, Baevsky stress index, are measured with an electrocardiogram (ECG) FAROS 180 from Bitium and evaluated via the software Kubios. There are 3 measurement points: T1 before the intervention, T2 after the intervention, T3 after 2 days. The measurement duration is 10 minutes each, whereby 5 minutes are evaluated via Kubios. The evaluation is carried out using a single-factor analysis of variance with measurement repetition. All measurement parameters are compared within the group and between the groups, as well as between the 3 measurement points.	—

Measure

Time frame

The measurement parameters of heart rate variability RMSSD, pNN50, TP, SDNN, LF, HF, LF/HF, Baevsky stress index, are measured with an electrocardiogram (ECG) FAROS 180 from Bitium and evaluated via the software Kubios. There are 3 measurement points: T1 before the intervention, T2 after the intervention, T3 after 2 days. The measurement duration is 10 minutes each, whereby 5 minutes are evaluated via Kubios. The evaluation is carried out using a single-factor analysis of variance with measurement repetition. All measurement parameters are compared within the group and between the groups, as well as between the 3 measurement points.

—

Secondary

Measure	Time frame
Age, sex, height, weight, previous illnesses, current medication, date of infection Sars-cov-2, vaccination status, acute course: No symptoms, Cold without fever, Cold with fever, Shortness of breath and cough, Hospitalisation, Symptoms at baseline recorded with a numerical scale from 0 to 10 Shortness of breath on exertion, muscular problems on exertion such as climbing stairs, persistent cough, palpitations, increased tiredness, fatigue, joint and muscle pain, smelling and tasting, balance or dizziness, word-finding disorders, attention disorders Anxiety, sheep disorders, listlessness and lack of interest. Zink-Test (ostepathic assesment)	—

Measure

Time frame

Age, sex, height, weight, previous illnesses, current medication, date of infection Sars-cov-2, vaccination status, acute course: No symptoms, Cold without fever, Cold with fever, Shortness of breath and cough, Hospitalisation, Symptoms at baseline recorded with a numerical scale from 0 to 10 Shortness of breath on exertion, muscular problems on exertion such as climbing stairs, persistent cough, palpitations, increased tiredness, fatigue, joint and muscle pain, smelling and tasting, balance or dizziness, word-finding disorders, attention disorders Anxiety, sheep disorders, listlessness and lack of interest. Zink-Test (ostepathic assesment)

—

Countries

Germany

Contacts

Public ContactAndreas Rembert Koczulla

Schön Klinik Berchtesgadener Land

Rgloeckl@schoen-klinik.de+498652931540

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026