C71
Conditions
Interventions
Group 1: In patients, 3 stimulation spots (over the tumor, adjacent to the tumor, contralateral) will be stimulated with 150 TMS pulses while an EEG is recorded.
Group 2: In healthy controls, 2 stimul
Sponsors
Klinik für Neurochirurgie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age above 18 years, Written informed consent; Only patients: Suspected brain tumor after MRI, Participation in TMS measurement
Exclusion criteria
Exclusion criteria: Contraindications for receiving an MRI, Contraindications for receiving a TMS measurement, More than one generalized seizure per week, Pregnancy, Missing conset to participate in the study; Only healthy controls: History of psychiatric or neurological diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amplitude of low-frequency TEP-components (< 4Hz) 8-350ms after the TMS pulse | — |
Secondary
| Measure | Time frame |
|---|---|
| Power of high-frequency EEG components (>20Hz) 150-350ms after the TMS pulse; Local and global signal complexity measured as PCIst; Resting-state power spectral density of the 4 EEG-electrodes around the respective stimulation sites; Number of deflections in the EEG signal; Motor status measured with the BMRC for upper and lower extremities; Finger tapping score; Time required to perform the 9-hole peg test; Aachener Aphasie Test Score; Montreal-Cognitive Assessment Test Score | — |
Countries
Germany
Contacts
Public ContactMelina Engelhardt
Klinik für Neurochirurgie, Charité Universitätsmedizin Berlin
Outcome results
None listed