Autism spectrum disorder F20 F40.1 F42
Conditions
Interventions
Group 1: Patients with Autism Spectrum Disorder (ASD), Schizophrenia (SCZ), Social Phobia (SAD) and Obsessive Compulsive Disorder (OCD) and healthy controls will be examined using fMRI, motion trackin
Sponsors
Institut für klinische Neurowissenschaften und medizinische Psychologie, Heinrich-Heine-Universität Düsseldorf
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: 4 groups of patients / participants which fulfill following criteria: - Healthy controls (n = 60) - ASD patients as diagnosed based on ADOS-2/ADI-R and a clinical assessment by a qualified psychiatrist (n = 60). - SCZ patients as diagnosed based on a clinical assessment by a qualified psychiatrist (n = 60) - SAD patients as diagnosed on a clinical assessment by a qualified psychiatrist (n = 60). - OCD patients as diagnosed on a clinical assessment by a qualified psychiatrist (n = 60). - Ability to understand the study procedure - Informed consent: A declaration of informed consent has to be signed and personally dated by the subject.
Exclusion criteria
Exclusion criteria: - Presence of disorders other than ASD, SCZ, SAD and OCD, which may deteriorate social functioning, motor function or cognitive abilities such as dementia, severe arthritis, drug/alcohol abuse, Alzheimer’s Disease, or stroke. However, because of high co-occurrence rate of conditions such as depressive disorders in ASD, SCZ, SAD and OCD, such disorders will be controlled for in the analyses but will not constitute a hard exclusion criterion. We will, however, attempt to recruit mainly individuals with no comorbidities. - Inability to remain motionless in the fMRI scanner without involuntary movements providing intolerable artifacts - Inability to give informed consent - Claustrophobia - Pregnancy - MRI incompatible implants, such as cardiac pacemakers or magnetic objects - Permanent makeup - Large tattoos particularly in or near the imaging area Abandon criteria: - Occurrence of any exclusion criterion either at the time of recruitment or revealed after/during measurement such as incidental findings in the MRI images - The patient’s / participant’s decision to abandon the study at any time - Withdrawal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameter differences in motion tracking | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain function differences in fMRI and differences in tracking app activity logs | — |
Countries
Germany
Contacts
Public ContactLeonhard Schilbach
Klinik und Poliklinik für Psychiatrie und Psychotherapie, LVR-Klinikum Düsseldorf, Kliniken der Heinrich-Heine Universität
Outcome results
None listed