I20.1
Conditions
Interventions
Group 1: To determine whether the flicker test is an appropriate diagnostic tool, dynamic vascular imaging using the retinal flicker test (IMEDOS) will be performed in patients with confirmed coronary
Sponsors
Charité Campus Virchow-Klinikum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Presence of written informed consent - Flow catheter examinations reveal that the patient has endothelial dysfunction (vasospastic angina) - Ability to give consent - Existing health insurance
Exclusion criteria
Exclusion criteria: - Intolerance to the active ingredient tropicamide, existing glaucoma, tachycardia, heart failure, myasthenia gravis, hyperthyroidism, acute pulmonary edema, obstructive urinary tract disease, rhinitis sicca, Down syndrome, epilepsy, pregnancy or lactation. - Any form of substance abuse, psychiatric disorder, or other condition that, in the opinion of the study physician(s), may invalidate communication with designated study personnel - Patients who are unable to provide informed consent voluntarily (e.g., persons under legal guardianship) - Patients who are institutionalized due to a court or administrative order.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of a noninvasive diagnostic method for vasospastic angina using state-of-the-art dynamic vascular imaging of the retinal microvasculature ("retinal flicker test"). | — |
Secondary
| Measure | Time frame |
|---|---|
| Single cell sequencing, immunohistochemical staining of tissue and flow cytometry of blood | — |
Countries
Germany
Contacts
Public ContactCarsten Tschöpe
Medizinische Klinik mit Schwerpunkt Kardiologie
Outcome results
None listed