G54.6 G54.0
Conditions
Interventions
Group 1: longitutinal: arm amputees
Group 2: longitudinal: patients with lesions of brachial plexus
Group 3: healthy controls
Sponsors
Friedrich-Schiller-Universität Jena; Klinische Psychologie
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: - Arm 1: Subjects with upper extremity amputations with pain sensation - Arm 2: Subjects with brachial plexus injury with paralyzed arm and pain sensation - Arm 3: Healthy subjects matched for sex and age with subjects from arms 1 and 2 - Sufficient cognitive and communication skills to participate in a series of tests and understand instructions
Exclusion criteria
Exclusion criteria: - Age under 18 or over 80 years - Severe neurological comorbidity that limits cognition and movement beyond the arm - Severe functional limitations of both arms - Manifest mental disorders (e.g., post-traumatic stress disorder, anxiety disorders), addictive behavior, defined as the abuse of drugs - Visual limitations that interfere with viewing the virtual image without interference - Pregnancy - Reasons to exclude from MEG and/or MRT investigation (ferromagnetic parts in the body, cochlea implants, heart pacemakers etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of cortical reorganization after the use of VR therapy systems (post vs. baseline), measured as changes in dipole localizations to tactile stimulation of lips and fingers as well as changes in activation by movements in fMRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of pain after the use of VR therapy systems (post vs. baseline); changes in resting state fMRI and functional connectivity e.g. during pain assessment | — |
Countries
Germany
Contacts
Public ContactThomas Weiß
Friedrich-Schiller-Universität Jena; Klinische Psychologie
Outcome results
None listed