J06.9
Conditions
Interventions
Group 1: Application of mouth wash containing HOCl 3 times per day and nasal spray containing HOCl 5 times per day for 10 days
Group 2: Application of placebo mouth wash 3 times per day and placebo na
Sponsors
Technische Universität DresdenInstitut für Klinische Pharmakologie
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Persons = 18 years old, capable to give informed consent - acute respiratory infection with symptoms like sore throat, cough, sneezing, fever - symptom onset was not more than 72 h ago
Exclusion criteria
Exclusion criteria: - Recent (during the last 4 weeks before inclusion in the study) or regular use of HOCl containing or other products for disinfection of oral or nasal mucosa (e.g. chlorhexidine) - Use of nasal medicines during the study - Antiviral therapy (e.g. Paxlovid) - Known or suspected hypersensitivity against ingredients of the test product or placebo - Pregnancy, breast feeding - Hospitalization due to COVID-19 symptoms - Cognitive impairment - Oxygen therapy, inhalative therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • percentage of patients with increase of symptoms between days 3 and 10 (questionnaire) | — |
Secondary
| Measure | Time frame |
|---|---|
| • Days until continuously negative antigen test • Decrease of viral load between day 0 / 1 and day 4-6 (quantitative PCR) | — |
Countries
Austria, Germany
Contacts
Public ContactGabriele Stöcker
Technische Universität DresdenInstitut für Klinische Pharmakologie
Outcome results
None listed