Evaluation of CD26/DPP4 expression in thymic epithelial tumours and in thymic tissue of patients with myasthenia gravis

Evaluation of CD26/DPP4 expression in thymic epithelial tumours and in thymic tissue of patients with myasthenia gravis - CD26/DPP4

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00030635

Enrollment

150

Registered

2023-01-23

Start date

2023-01-23

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C37

Interventions

Group 1: Study with retrospective data collection and prospective staining of existing tissue samples

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with histologically proven thymic epithelial tumours (thymoma and thymic carcinoma), thymic hyperplasia and/or a diagnosis of myasthenia gravis. 2. Treatment at the Department of Thoracic Surgery at the University of Freiburg Medical Center between January 2006 and September 2022 3. Written informed consent from living individuals or meeting the criteria defined in the “Merkblatt zur Nutzung von Altproben” (Version November 2014) of the ethics committee. 4. Sufficient tissue availability at the Institute of Clinical Pathology.

Exclusion criteria

Exclusion criteria: none

Design outcomes

Primary

Measure	Time frame
Expression of CD26/DPP4 in thymic epithelial tumours and thymic tissue of patients with myasthenia gravis.	—

Secondary

Measure	Time frame
- To correlate the expression of CD26/DPP4 with the histologic subtype, TNM and Masaoka-Koga Stadium, the overall and relapse-free survival in thymic epithelial tumours. - To correlate the expression of CD26/DPP4 in thymic tissue with the clinical course in patients with Myasthenia gravis	—

Countries

Germany

Contacts

Public ContactBirte Ohm

Universitätsklinikum Freiburg, Klinik für Thoraxchirurgie

birte.ohm@uniklinik-freiburg.de+49 761 27024570

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026