F00 I68.0
Conditions
Interventions
Group 1: Patients with an Alzheimer's disease diagnosis according to the NIA-AA Research Framework criteria (Jack et al., 2018) and/or possible or probable CAA diagnosis according to the Boston criter
Sponsors
Klinik für Neurologie Uniklinik RWTH Aachen
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: Written declaration of consent from the study participant in the case of capacity to consent
Exclusion criteria
Exclusion criteria: - Contraindication for MRI examination - Other causes of intracranial haemorrhage or cortical haemosiderosis other than CAA (e.g. acquired or hereditary coagulation or platelet aggregation disorders, intracranial vascular malformations, CNS vasculitis, significant traumatic brain injury). - Hereditary AD or hereditary CAA - Severity of cognitive impairment according to the Global Deterioration Scale >= 5 (GDS; GDS 5 = moderate dementia) - Atypical phenotypic presentation of AD, such as logopenic primary progressive aphasia or posterior cortical atrophy (PCA)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of the discriminatory role of vascular reactivity in the CAA-AD continuum based on abnormal BOLD activity (functional MRI) in the occipital lobes over the course of disease (baseline vs. follow-up 24 months). | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between reduced visual vascular reactivity (BOLD signal) with clinical standardised test procedures of visual spatial processing. | — |
Countries
Germany
Contacts
Public ContactAna Sofa Costa
Klinik für Neurologie, Uniklinik RWTH Aachen
Outcome results
None listed