inhalative and non-inhalative nicotine consumption
Conditions
Interventions
Group 1: spiroergometry following filter cigarette comsumption
Group 2: spiroergometry following e-cigarette consumption
Group 3: spiroergometry following nicotine pouch consumption
Group 4: spiroergo
Sponsors
UKSH Lübeck
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: -Age of at least 18 years -BMI 20-27,5kg/m² -no previous medical conditions -occasional but not daily nicotine consumption - e.g. via filter cigarette -consent to the study protocol with written informed consent -pregnancy excluded or safe continued hormonal contraception
Exclusion criteria
Exclusion criteria: -strict non-smokers -People who have consumed nicotine within 48h before the measurement -Disorders of the musculoskeletal system that do not allow spiroergometry to be performed -acute viral or bacterial infections -serious illnesses which, in the opinion of the study directors, endanger the safety of the participant during the study, especially during exercise -serious arrhythmias, heart defects -pregnancy or lactation -drug abuse other than nicotine -Participation in another drug or medical device study -lack of compliance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum oxygen uptake after consumption of various nicotine applications compared to a control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| -Comparison of the four experimental arms before performing spiroergometry regarding peripheral and central hemodynamics as well as arterial vascular stiffness and small airways. -Variation of the mentioned parameters after the exercise situation over 30 minutes with set measurement time points (Mobil-O-Graph every 5 minutes, Small Airways after 5, 10, 15 and 30 minutes). -Comparison of parameters of physical performance, heart rate and airway reserve of the four experimental arms. | — |
Countries
Germany
Contacts
Public ContactKlaas Franzen
UKSH Lübeck
Outcome results
None listed