Children with a body weight between 4kg and 20kg undergoing cardiac surgery
Conditions
Interventions
Group 1: 20 patients with ventilation stop at HLM (aortic X-clamp)
Group 2: 20 Pat with CPAP 5 mmHg at HLM (aortic X-clamp)
Group 3: 20 Pat with lung protective ventilation at HLM (aortic X-clamp)
Sponsors
Universitätsklinikum
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Children who are undergoing cardiac surgery. Body weight between 4 and 20 kg Prior education and informed, written consent of the legal guardian/caregiver
Exclusion criteria
Exclusion criteria: Body weight less than 4 kg or more than 20 kg Lack of consent of parent/guardian >ASA 4 Emergency Contraindications to thoracic EIT according to intended purpose (e.g., cardiac pacing)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination and comparison of pre- and postoperative regional homogeneity of pulmonary ventilation after intraoperative apnea/CPAP/lowVT ventilation using common EIT parameters (GI index, RVD index, ITV index). | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences between spontaneous and mechanical ventilation Existing age differences (global ventilation) Different zones of ventilation (ventral/dorsal) Relationship between postoperative ventilation distribution and gas exchange parameters (PaO2, PaCO2, volumetric capnometry) Influence of intraoperative ventilation strategy on pulmonary epithelial damage (SP-B/D, RAGE) and inflammatory activation (IL-6, IL-8) | — |
Countries
Germany
Contacts
Public ContactEhrenfried Schindler
Universitätsklinikum Bonn
Outcome results
None listed