Basic research on deposition of drugs in oral biofilm
Conditions
Interventions
Group 1: Plaque is grown in the mouth of the subjects on splints and on the teeth. The splint is regularly incubated in a solution of forensically relevant drugs (amphetamine, methamphetamine and ecst
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: -unremarkable general medical history -Age between 18 and 65 years -healthy according to the investigator's assessment -In females: at least one method of contraception accepted by conventional medicine -naturally healthy or rehabilitated dentition -Written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: -For women: Pregnancy -For women: Breastfeeding -Rejection of written consent -Allergies to the materials used in the examination (especially plastic components) -Non-sanitized dentition or pending dental treatment other than emergency treatment -Intake of medications/drugs/foodstuffs that impair the detection of the test substances -Intake of antibiotics within the last 2 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of the concentration of the relevant substances in the biofilm and, as a reference, in saliva and tongue coating Characterization of the biofilm by means of microscopy and microbiome analysis | — |
Secondary
| Measure | Time frame |
|---|---|
| Measurement of the concentration of the relevant substances in the biofilm and, as a reference, in saliva and tongue coating Characterization of the biofilm by means of microscopy and microbiome analysis | — |
Countries
Germany
Contacts
Public ContactMarkus Altenburger
Klinik für Zahnerhaltungskunde und Parodontologie Department für Zahn-, Mund- und Kieferheilkunde Universitätsklinikum Freiburg
Outcome results
None listed