Impact of macrophage polarization on the efficacy of surgical therapy of peri-implantitis

Impact of macrophage polarization on the efficacy of surgical therapy of peri-implantitis - Pi-Makrophagen

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00030110

Enrollment

Registered

2022-09-08

Start date

2022-09-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periimplantitis K10.28

Interventions

Group 1: Clinical basis examination (PD, BOP, MM, Supp, PI): Initial, after 6, 12, 24, 36,48, 62 months

Histological at surgery time

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: (1) minimum age of 18 years old; (2) partially/totally edentulous patients exhibiting titanim dental implants diagnosed with moderate or advanced peri-implantitis; (3) presence of keratinized mucosa = 2 mm (4) intrabony defect depth = 3mm; (5) plaque index <1 (Löe, 1967) prior to surgery.

Exclusion criteria

Exclusion criteria: (1) untreated periodontal disease and insufficient oral hygiene; (2) pregnant or lactant women; (3) autoimmune or/and inflammatory diseases; (4) uncontrolled diabetes (HbA1c>7); (5) corticosteroid therapy.

Design outcomes

Primary

Measure	Time frame
To evaluate the influence of the M1/M2 ratio on the clinical outcomes following reconstructive surgical therapy of moderate to advanced peri-implantitis lesions	—

Countries

Germany

Contacts

Public ContactTanja Eisenbach

Poliklinik für Zahnärztliche Chirurgie und Implantologie, Zentrum für Zahn-, Mund- und Kieferheilkunde (Carolinum)

eisenbach@med.uni-frankfurt.de069 6301 7530

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026