Impact of remote ischemic preconditioning (RIPC) on kidney function and microRNA-signature of extracellular vesicles following partial nephrectomy: a randomized, prospective trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00030081

Enrollment

170

Registered

2022-08-26

Start date

2022-09-12

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

C64

Interventions

Group 1: RIPC group Group 2: Sham group (no RIPC preoperatively)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - kidney tumor - partial nephrectomy technically feasible

Exclusion criteria

Exclusion criteria: intraoperative conversion to nephrectomy

Design outcomes

Primary

Measure	Time frame
Postoperative renal function (measured as creatinine, 24 hour-urine, cystatin C und the following biomarkers in plasma and urine: IGFBP7, TIMP-2, KIM-1, NGAL, Vanin-1, NAG, uRBP4, DKK-3) at 24h, 3 and 90 days postoperatively	—

Secondary

Measure	Time frame
Concentration of EV and microRNA-signature from plasma at the following time points: T1: Before anesthesia T2: 5 minutes after RIPC T3: 5 minutes before clamping of renal artery T4: 5 minutes after declamping T5: end of operation	—

Countries

Germany

Contacts

Public ContactLorine Häuser

Marien Hospital Herne Klinik für Urologie und Neuro-Urologie

lorine.haeuser@rub.de02323- 499 5306

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026