The Efficacy of Regeneration Oil and Almond Oil on Split-Thickness Skin Graft Donor Sites: A Single-Blinded Randomized Controlled Trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00030072

Enrollment

Registered

2022-08-25

Start date

2015-03-02

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reepithilialized (healed) split-thickness skin graft donor sites Z94.5

Interventions

Group 1: Almond oil (oleum amygdalae, Gatt-Koller GmbH, Absam, Austria). Application of the oil to the healed split-thickness skin graft donor site 2x daily for 6 months. Group 2: Regeneration oil (A

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Patients with split-thickness skin graft (donor site thigh)

Exclusion criteria

Exclusion criteria: - Allergy or known allergic reaction to any of the oils used in the study - Heart disease with a negative impact on skin blood flow - Active tumor diseases - congenital and acquired diseases of the immune system - Anemia (hemoglobin <10g/dl or hematocrit <35%) - Autoimmune diseases - Acute/chronic kidney failure with serum creatinine values ??above 176 mmol/l or kidney disease requiring dialysis - Liver cirrhosis, active liver infection/inflammation (hepatitis) - Alcohol or drug addiction - Severely underweight and cachectic patients (Body Mass Index <16) - Thyroid dysfunction affecting the basal metabolic rate - Diabetes mellitus - Pregnancy, lactation - Rejection of the study, lack of willingness to cooperate

Design outcomes

Primary

Measure	Time frame
- scar quality (Patient and Observer Scar Assessment Scale) after 1, 3, 6 months. - itching (ITCH Man Scale) after 1, 3, 6 months	—

Secondary

Measure	Time frame
scar discoloration (colorimetry) after 1, 3, 6 months	—

Countries

Austria

Contacts

Public ContactDavid-Benjamin Lumenta

Medizinische Universität Graz, Abteilung für Plastische Ästhetische und Rekonstruktive Chirurgie

david.lumenta@medunigraz.at+43 316 385 81205

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026