DSM V Major Depressive Disorder
Conditions
Interventions
Group 1: 25 patients with a major depressive disorder will be investigated with 7 T MRI as well as EEG and evoked potentials. Moreover, psychopathology will be assessed and breath gas will be collecte
Sponsors
Universitätsklinikum der RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: depressive episode according to DSM V (major depressive disorder) being able to understand the study procedure
Exclusion criteria
Exclusion criteria: - Exclusion criteria for the performance of an MRI examination - Pregnancy in women - current (present or in the last 4 weeks) treatment with an antidepressant drug - depressive episode with psychotic symptoms - acute suicidality, suicidal intent, or suicidal plans - alcohol and/or drug dependence according to DSM-V - history of drug-induced psychosis - organic diseases affecting brain function (hormonal diseases, e.g. thyroid disease) - subjects that cannot communicate during the MRI scanning via the speaker with the MR employees due to illness related disturbances or disturbances as side effects of medication - infectious diseases, bronchial asthma, and other diseases affecting the pulmonary system - current cancer (or in the last year) - neurological diseases such as Parkinson's disease, stroke, multiple sclerosis - diabetes mellitus - comorbid axis I disease - patients participating in another clinical investigation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| volatile organic compounds from breath will be measured at the day of investigation. Subjects will breath for this into Teddlar bags and then VOCs will be measured afterwards from the Teddlar bags. | — |
Secondary
| Measure | Time frame |
|---|---|
| metabolites from MR spectroscopy depression severity | — |
Countries
Germany
Contacts
Public ContactThomas Frodl
Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Uniklinik RWTH Aachen
Outcome results
None listed