Molecular characterization of fertilization markers in ejaculate.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029986

Enrollment

100

Registered

2022-10-31

Start date

2023-02-03

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N46

Interventions

Group 1: Cohort A: Ejaculate samples from patients with normozoospermia. Retrospective fertilisation marker analysis based on proteins known from the literature from diagnostic surplus material of the

Eligibility

Sex/Gender

Male

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: All ejaculate samples obtained for diagnostic purposes in the context of a fertility clinic.

Exclusion criteria

Exclusion criteria: post vasectomy

Design outcomes

Primary

Measure	Time frame
The primary aim of the study is to identify markers by retrospective histo/molecular genetic analysis of mRNA, miRNA and proteins from purified ejaculate samples using proteins known from the literature. The analysis is carried out from diagnostic surplus material of ejaculate analyses performed in our department. Comparison of the occurrence between cohort A (normozoospermia) and B (restrictions in the spermiogram). No experimental therapy is performed and no additional measures are taken.	—

Measure

Time frame

The primary aim of the study is to identify markers by retrospective histo/molecular genetic analysis of mRNA, miRNA and proteins from purified ejaculate samples using proteins known from the literature. The analysis is carried out from diagnostic surplus material of ejaculate analyses performed in our department. Comparison of the occurrence between cohort A (normozoospermia) and B (restrictions in the spermiogram). No experimental therapy is performed and no additional measures are taken.

—

Countries

Germany

Contacts

Public ContactJan Herden

Uniklinik Köln, Klinik für Urologie

jan.herden@uk-koeln.de0221 47882037

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026