Early Detection of Sepsis and Severe Sepsis in Patients by Point of Care Diagnostics (SEPTOMETER)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029970

Enrollment

100

Registered

2022-10-13

Start date

2017-06-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

A41

Interventions

Group 1: SIRS Group 2: Sepsis Group 3: Severe sepsis

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Patients with SIRS and patients with sepsis in the Surgical Intensive Care Unit.

Exclusion criteria

Exclusion criteria: age <18 years, immunosuppression, pregnancy, need for ECMO therapy and neurosurgical main diagnosis

Design outcomes

Primary

Measure	Time frame
Early detection of sepsis in SIRS patients based on progranulin plasma concentration with a specificity = 73% and a sensitivity of = 80% at least 6 h before sepsis diagnosis supported by standard laboratory chemistry tests.	—

Secondary

Measure	Time frame
Early detection of severe sepsis based on s-adenosylhomocysteine plasma concentration in patients with sepsis with a specificity = 73% and a sensitivity of = 80% at least 6 hours before clinical manifestation of organ dysfunction.	—

Countries

Germany

Contacts

Public ContactManfred Thiel

Universitätsmedizin Mannheim Klinik für Anästhesie und Operative Intensivmedizin

Manfred.thiel@medma.uni-heidelberg.de06213838635

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026