The influence of synovialitis on the clinical outcome of knee joint preserving surgery.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029949

Enrollment

600

Registered

2022-08-02

Start date

2022-08-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M23 S83.50 M23.9

Interventions

Group 1: - Evaluation of the treatment at the knee joint within the clinical routine including MRI diagnostics. - Central evaluation of synovialitis samples (taken within the routine treatment) by th

Eligibility

Sex/Gender

All

Age

18 Years to 69 Years

Inclusion criteria

Inclusion criteria: 1) Upcoming joint-preserving knee joint surgery (arthroscopic and open): Partial meniscus resection, anterior cruciate ligament replacement surgery, cartilage reconstructive surgery (any technique). 3) Capacity to give consent 4) Participation in the DART registry (can also be done just prior to study inclusion).

Exclusion criteria

Exclusion criteria: 1) Autoimmune diseases 2) Concomitant injury to the extremity on which the knee joint procedure is scheduled. 3) Acquired (i.e., drug-induced) immunosuppression (excluding perioperative use of NSAIDs). 4) Congenital immunosuppression

Design outcomes

Primary

Measure	Time frame
Correlation of the severity of knee joint synovitis (inflammation of the synovium) at the time of surgery with postoperative clinical outcome by regression analysis. H0: The severity of synovitis at the time of surgery does not correlate with clinical outcome. H1: The severity of synovitis at the time of surgery correlates with clinical outcome.	—

Secondary

Measure	Time frame
If, according to H1, there is a correlation of the severity of knee joint synovitis (inflammation of the synovium according to Krenn 0-9) at the time of surgery with the clinical outcome or the radiological outcome, factors predictive of outcome will be identified. Correlation of the expression of knee joint synovitis (inflammation of the synovium according to Krenn 0-9) at the time of the operations with the initial MRI of the knee joint. Correlation of the degree of knee joint synovialitis with the individual clinical pictures, e.g. meniscus lesion, anterior cruciate ligament rupture, cartilage damage.	—

Measure

Time frame

If, according to H1, there is a correlation of the severity of knee joint synovitis (inflammation of the synovium according to Krenn 0-9) at the time of surgery with the clinical outcome or the radiological outcome, factors predictive of outcome will be identified. Correlation of the expression of knee joint synovitis (inflammation of the synovium according to Krenn 0-9) at the time of the operations with the initial MRI of the knee joint. Correlation of the degree of knee joint synovialitis with the individual clinical pictures, e.g. meniscus lesion, anterior cruciate ligament rupture, cartilage damage.

—

Countries

Germany

Contacts

Public ContactKaywan Izadpanah

Universitätsklinikum Freiburg Klinik für Orthopädie und Unfallchirurgie

kaywan.izadpanah@uniklinik-freiburg.de0761 270-28010

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026