Effect of noninvasive auricular vagus nerve stimulation on cerebral motor excitability

Effect of noninvasive auricular vagus nerve stimulation on cerebral motor excitability - ENLARGE

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029937

Enrollment

Registered

2022-08-29

Start date

2023-04-05

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

study on healthy participants

Interventions

Group 1: VNS sham stimulation site: left earlobe intensity: perception threshold frequency: 5Hz pulse width: 200-300ms on-off-time: 30 sec duration: 30min Group 2: VNS intervention perception thresho

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: age between 18 and 50

Exclusion criteria

Exclusion criteria: - Acute and chronic disease (e.g. skin disease, cardiovascular, neurological or psychiatric disease) - Medication use - History of epileptic seizures in the past - Metal implants - Pregnancy

Design outcomes

Primary

Measure	Time frame
1. tVNS alters the recruitment curves. 2. tVNS alters SICI. 3. tVNS alters ICF.	—

Secondary

Measure	Time frame
1. The effects on motor excitability are modulated by the tVNS intensity. 2. There is no difference between the dominant and non-dominant hemisphere.	—

Countries

Germany

Contacts

Public ContactMatthias Grothe

Universitätsmedizin GreifswaldKlinik und Poliklinik für Neurologie

matthias.grothe@med.uni-greifswald.de0049-3834-866839

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026