K74
Conditions
Interventions
Group 1: Patients will be examined by a cardiac MRI 6 months before a liver transplantation with contrast agent and regadenoson. In addition, a blood sample will be taken to examine heart parameters
Sponsors
Universitätsklinikum Hamburg-Eppendorf
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients who received an uncomplicated CMRI before the LTX. Patients who, based on this CMRI, do not have any critical myocardial ischemia relevant to LTX.
Exclusion criteria
Exclusion criteria: Inability to give informed consent. Known, general contraindication for an MRI scan, such as the presence of a cardiac pacemaker or implantable defibrillator, ferromagnetic clips or intracranial clips, shrapnel, etc., Acute heart failure > NYHA III and/or rhythmic instability. Severe renal impairment with a glomerular filtration rate <30 mL/min/1.73 m2. Serious infectious diseases. Pregnancy. Age younger than 18 . Claustrophobia (fear of confined or confined spaces). Hypersensitivity to any of the active ingredients used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Normalization of the left ventricular ejection fraction (EF) as a reference parameter for the cardiac function 6 months after liver transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Normalization of "strain" as a newly established parameter for global and regional deformation the heart muscle fibers. Reduction of the "extracellular volume" as an indicator for an existing myocardial fibrosis. Occurrence of new, functionally relevant coronary stenoses. | — |
Countries
Germany
Contacts
Public ContactJennifer Erley
UKE, Radiologie
Outcome results
None listed