Assessing a low iohexol dose as a marker of glomerular filtration rate in healthy volunteers

Assessing a low iohexol dose as a marker of glomerular filtration rate in healthy volunteers - LOWIO

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029908

Enrollment

Registered

2022-12-16

Start date

2023-01-10

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adult healthy male and female non-smokers

Interventions

Group 1: Volunteers receive a low dose of iohexol (259 mg) in fasted state Group 2: Volunteers receive a high dose of iohexol (3235 mg) in fasted state Group 3: Volunteers receive a high dose of iohex

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Standard criteria for healthy individuals, non-smoker

Exclusion criteria

Exclusion criteria: Subjects with contraindications for iohexol

Design outcomes

Primary

Measure	Time frame
Main pharmacokinetic parameters of iohexol: CL; ratio of CL between the low and the high dose	—

Secondary

Measure	Time frame
Further pharmacokinetic parameters of iohexol and creatinine as generated by the population pharmacokinetic evaluation Safety and Tolerability: • Medical history, AEs and well-being • Laboratory screen (haematology, clinical chemistry, urinalysis and TSH) • Alcohol breath test, drug screening, pregnancy tests (females only) • Physical examination • Vital functions: BP, PR and body temperature • 12-lead ECG	—

Measure

Time frame

Further pharmacokinetic parameters of iohexol and creatinine as generated by the population pharmacokinetic evaluation Safety and Tolerability: • Medical history, AEs and well-being • Laboratory screen (haematology, clinical chemistry, urinalysis and TSH) • Alcohol breath test, drug screening, pregnancy tests (females only) • Physical examination • Vital functions: BP, PR and body temperature • 12-lead ECG

—

Countries

Germany

Contacts

Public ContactUwe Fuhr

Institut I für Pharmakologie des Universitätsklinikums Köln (AöR)

uwe.fuhr@uk-koeln.de0221/478-5230

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026