Right ventricular pump function in pulmonary hypertension and obesity

Right ventricular pump function in pulmonary hypertension and obesity - PH-obesity

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029726

Enrollment

Registered

2022-07-29

Start date

2022-08-17

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I27.0 E66

Interventions

Group 1: Investigation of the correlation between right ventricular pump function and BMI in PH-Patients Underweight <18,5 kg/m2 Normal range 18,5-24.9 kg/m2 Overweight 25-29.9 kg/m2 obese =30 kg/m2

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Adult patients with pre-capillary pulmonary hypertension, defined as mPAP =25 mmHg and PAWP =15 mmHg and Consent by "Broad Consent der Lungenbiobank Heidelberg der Datenverarbeitung von Daten der klinischen Routine" (retrospective inclusion) or the specific declaration of consent (prospective inclusion).

Exclusion criteria

Exclusion criteria: - Minors and patients incapable of consent - Patients with congenital or acquired heart defects with a shunt - Acute cardiac decompensation - patients with unclear determination of body weight or evidence of incorrect determination of body weight

Design outcomes

Primary

Measure	Time frame
Investigation of the correlation between right ventricular pump function and BMI in PH-Patients Underweight <18,5 kg/m2 Normal range 18,5-24.9 kg/m2 Overweight 25-29.9 kg/m2 obese =30 kg/m2 Acquired by first right heart catheterization of the patient.	—

Secondary

Measure	Time frame
- Investigation of the correlation between right ventricular pump function and BMI as well as influencing factors. - RV pump function as determined by right heart catheterization (RHC) (haemodilution and/or Fick method) and echocardiography. The aim of these analyses is to investigate whether the RV pump function in overweight or underweight patients may be overestimated or underestimated in RHC and wether there are contributing factors. Group comparisons based on the BMI groups for the following parameters: right cardiac catheterization - Cardiac Output (CO) - Cardiac Index (CI) - Stroke volume (SV) - Stroke Volume Index (SVI) - Pulmonary vascular resistance (PVR) - Pulmonary Vascular Resistance Index (PVRI) - Pulmonary Arterial Compliance (PAC) - Central vein pressure - Systolic and diastolic pressure of the right ventricle (RVP (s/d)) - Right ventricular enddiastolic pressure (RVEDP) - Systolic, diastolic and mean pulmonary artery pressure (PAP (s/d/m)) - Pulmonary capillary occlusive pressure (PAWP) Echocardiography: - Right atrial area - Right ventricular area - Tricuspid annular plane systolic excursion (TAPSE) - RV pump function (visually assessed) - All other methods to determine the RV function (e. g. speckle tracking, strain, strain rate) - RV wall thickness - Parameters for diastolic RV and LV function, all routine parameters for assessing LV and LA size and function, heart valves, pericardium, exclusion of heart vitia - Pressure and flow determinations, PA-pressures Correlation of BMI and CO with - Gender - Age - WHO functional class - 6-minute walking test - Lung function parameters o forced vital capacity o total lung capacity o Diffusion capacity of carbon monoxide o forced expiratory volume per second - Laboratory routine parameter o Leukocyte count o C-reactive protein o N-terminals pro brain natriuretic peptide o Troponin T o urea o Estimated glomerular filtration rate o Creatinine Examinati	—

Measure

Time frame

- Investigation of the correlation between right ventricular pump function and BMI as well as influencing factors. - RV pump function as determined by right heart catheterization (RHC) (haemodilution and/or Fick method) and echocardiography. The aim of these analyses is to investigate whether the RV pump function in overweight or underweight patients may be overestimated or underestimated in RHC and wether there are contributing factors. Group comparisons based on the BMI groups for the following parameters: right cardiac catheterization - Cardiac Output (CO) - Cardiac Index (CI) - Stroke volume (SV) - Stroke Volume Index (SVI) - Pulmonary vascular resistance (PVR) - Pulmonary Vascular Resistance Index (PVRI) - Pulmonary Arterial Compliance (PAC) - Central vein pressure - Systolic and diastolic pressure of the right ventricle (RVP (s/d)) - Right ventricular enddiastolic pressure (RVEDP) - Systolic, diastolic and mean pulmonary artery pressure (PAP (s/d/m)) - Pulmonary capillary occlusive pressure (PAWP) Echocardiography: - Right atrial area - Right ventricular area - Tricuspid annular plane systolic excursion (TAPSE) - RV pump function (visually assessed) - All other methods to determine the RV function (e. g. speckle tracking, strain, strain rate) - RV wall thickness - Parameters for diastolic RV and LV function, all routine parameters for assessing LV and LA size and function, heart valves, pericardium, exclusion of heart vitia - Pressure and flow determinations, PA-pressures Correlation of BMI and CO with - Gender - Age - WHO functional class - 6-minute walking test - Lung function parameters o forced vital capacity o total lung capacity o Diffusion capacity of carbon monoxide o forced expiratory volume per second - Laboratory routine parameter o Leukocyte count o C-reactive protein o N-terminals pro brain natriuretic peptide o Troponin T o urea o Estimated glomerular filtration rate o Creatinine Examinati

—

Countries

Germany

Contacts

Public ContactEkkehard Grünig

Zentrum für pulmonale HypertonieThoraxklinik des UniversitätsklinikumsHeidelberg

ekkehard.gruenig@med.uni-heidelberg.de06221-396-1230

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026