Prospective study on the validity of different eGFR estimation methods based on biomarkers in patients with allogeneic stem cell transplantation

Prospective study on the validity of different eGFR estimation methods based on biomarkers in patients with allogeneic stem cell transplantation - allo-GFR

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029715

Enrollment

150

Registered

2022-09-19

Start date

2022-11-29

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

patients with allogeneic stem cell transplantation Z94.81

Interventions

Group 1: Adult, hospitalized patients of the Clinic and Polyclinic for Stem Cell Transplantation of the UKE, who are treated intravenously with one or more of the drugs aciclovir, ceftazidime, gancicl

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: • Adult, hospitalized patients of the Clinic and Polyclinic for Stem Cell Transplantation of the UKE, who are treated intravenously with one or more of the drugs ceftazidime, meropenem, piperacillin-tazobactam, vancomycin, aciclovir or ganciclovir according to the indication • Written consent from the patient

Exclusion criteria

Exclusion criteria: • Age < 18 years • Patients with cardiac pacemaker • Pregnant women • Lack of written consent from the patient

Design outcomes

Primary

Measure	Time frame
Correlation of GFR estimates based on creatinine and cystatin C with the clearance of renally eliminated anti-infectives. GFR is calculated using various formulas (including Cockroft-Gault, MDRD, CKD-EPI). The clearance of renally eliminated anti-infectives is determined using population pharmacokinetic models.	—

Secondary

Measure	Time frame
- The impact of muscle mass determined from imaging (CT) or by bioimpedance analysis (BIA) and the duration and intensity of steroid treatment (data from the electronic patient record) on the correlation of GFR estimates with the clearance of the anti-infectives examined. - Correlation of drug clearance (from population pharmacokinetic calculations) and creatinine clearance accurately measured from serum and urine data, as a measure of actual renal function.	—

Measure

Time frame

- The impact of muscle mass determined from imaging (CT) or by bioimpedance analysis (BIA) and the duration and intensity of steroid treatment (data from the electronic patient record) on the correlation of GFR estimates with the clearance of the anti-infectives examined. - Correlation of drug clearance (from population pharmacokinetic calculations) and creatinine clearance accurately measured from serum and urine data, as a measure of actual renal function.

—

Countries

Germany

Contacts

Public ContactEva-Maria Wansing

Klinikapotheke

e.wansing@uke.de040 / 741053047

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 7, 2026