Influence of inspiratory time in preterm infants <32 SSW with respiratory distress syndrome on respiratory mechanics and homogeneity of lung ventilation

Influence of inspiratory time in preterm infants <32 SSW with respiratory distress syndrome on respiratory mechanics and homogeneity of lung ventilation - ShortTI

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029705

Enrollment

Registered

2022-11-18

Start date

2022-12-01

Completion date

Unknown

Last updated

2025-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory mechanics and homogeneity of lung ventilation

Interventions

Group 1: Long inspiratory times vs. short inspiratory times. Over a period of 12 minutes, different inspiratory times (0.1-0.4s) are set and the breathing mechanics are assessed via intratidal respira

Eligibility

Sex/Gender

All

Age

No minimum to 7 Days

Inclusion criteria

Inclusion criteria: Gestational age < 32 bw, chronological age < 8 d, invasive ventilation (conventional ventilation or HFO) because of respiratory distress syndrome (radiologic, surfactant administration), tube leak less than 30%, signed informed consent from guardian.

Exclusion criteria

Exclusion criteria: Severe connatal pulmonary or cardiac malformations, chromosomal abnormalities, respiratory failure under invasive ventilation (pCO2 > 70 mmHg, FiO2 > 0.7).

Design outcomes

Primary

Measure	Time frame
Influence of inspiratory time on gas flow and airway pressure measured by intratidal respiratory mechanics analysis	—

Secondary

Measure	Time frame
Determination of the variability of time constants in preterm infants, influence of inspiratory time on compliance and resistance using intratidal respiratory mechanics analysis, influence of inspiratory time on transpulmonary pressures, influence of inspiratory time on the required inspiratory pressure at constant tidal volume, and influence of inspiratory time on lung ventilation measured by electrical impedance tomography.	—

Measure

Time frame

Determination of the variability of time constants in preterm infants, influence of inspiratory time on compliance and resistance using intratidal respiratory mechanics analysis, influence of inspiratory time on transpulmonary pressures, influence of inspiratory time on the required inspiratory pressure at constant tidal volume, and influence of inspiratory time on lung ventilation measured by electrical impedance tomography.

—

Countries

Germany

Contacts

Public ContactJana Baumgartner

Zentrum für Kinder- und Jugendmedizin, Universitätsklinikum Freiburg

jana.baumgartner@uniklinik-freiburg.de004976143000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026