CXCL4-induced PBMCs in extracellular vesicle-mediated vascular calcification and extracellular matrix modulation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029695

Enrollment

Registered

2022-07-27

Start date

2022-03-17

Completion date

Unknown

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I24

Interventions

Group 1: Healthy blood donors, from whom up to 200 ml of whole blood is drawn following written informed consent. The blood will be used for monocyte isolation for all further experiments and analyses

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: healthy blood donors

Exclusion criteria

Exclusion criteria: cardiovascular disease, other chronic diseases, long-term medication

Design outcomes

Primary

Measure	Time frame
The objective of this study is to polarize peripheral blood-derived monocytes into the M4 phenotype for downstream analyses. Herein, in vitro calcific potential as well as quantitative and qualitative EV release by this phenotype compared to M-CSF-induced monocytes shall be investigated.	—

Countries

Germany

Contacts

Public ContactJona B. Krohn

University Hospital Heidelberg

jona.krohn@med.uni-heidelberg.de06221/5634070

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026