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Pilot study to characterize the autonomic balance and the circadian rhythm in the course of a COVID-19 infection using Holter ECG

Pilot study to characterize the autonomic balance and the circadian rhythm in the course of a COVID-19 infection using Holter ECG - SARS-H-ECG

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
DRKS
Registry ID
DRKS00029687
Enrollment
25
Registered
2022-07-19
Start date
2022-04-25
Completion date
Unknown
Last updated
2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

I50

Interventions

Group 1: 1. Inclusion as part of the inpatient stay or an outpatient presentation (initial SARS-Cov 2 proof = 7 days) or at planned outpatient follow-up (<= 3 months) (only in patients with a clinical

Sponsors

Universitätsklinik für Pneumologie
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients in the final isolated stage of SARS-CoV-2 infection 2. Patients with sinus rhythm or patients with paroxysmal atrial fibrillation 3. Patient is able to obtain a Holter ECG 4. Signed Consent Form

Exclusion criteria

Exclusion criteria: 1. Patients with persistent or permanent atrial fibrillation 2. Patients who require permanent atrial pacing an HSM 3. Age < 18 years 4. Pregnancy or lactating 5. State after cardiac transplantation (HTX) 6. Chronic renal failure patients with stages 4 and 5 according to KDOQI 7. Patients with active tumor diseases undergoing chemotherapy/radiation therapy 8. Therapy with topical corticosteroid therapy

Design outcomes

Primary

MeasureTime frame
Collection of reference values of the sympatho-vagal balance as a value of the interaction of parasympathetic (HF) and sympathetic (LF) and parasympathetic activity (R-MSSD)

Secondary

MeasureTime frame
1) Exploratory data analysis of classic heart rate parameters and their correlation to clinical symptoms/patient diary 2) Comparison of sympatho-vagal balance (normal values/healthy (data from OvGU BIO|CONCEPT.ECG library) vs. SARS-CoV-2 in the no longer infectious stage 3) Validation of the applicability of the inZHerz (DRKS0002238) circadian profile 4) Artifact and security analysis

Countries

Germany

Contacts

Public ContactEsther Meyer

Universitätsklinik für Pneumolgie

esther.meyer@med.ovgu.de+49-391-67-24903

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026