Measurement of sleep-onset REM episodes during sleep with and without sleep deprivation- «SOREM Episodes: state or trait?»

Measurement of sleep-onset REM episodes during sleep with and without sleep deprivation- «SOREM Episodes: state or trait?» - MSLT_pro Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029645

Enrollment

Registered

2022-08-23

Start date

2022-09-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

G47.4 G47

Interventions

Group 1: Total sleep deprivation Group 2: First half night sleep deprivation Group 3: Second half night sleep deprivation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: • Subjective symptoms of daytime sleepiness (definition see below) • Epworth Sleepiness Scale (ESS) >10/24 points • At least 1 SOREM episode in previous routine MSLT and/or in routine PSG at time of diagnosis. • The patients must be at least 18 years old and no more than 80 years old • Ability and consent to electrophysiological testing • Ability to give informed consent

Exclusion criteria

Exclusion criteria: • Pregnant or breastfeeding women • Drug therapy with sodium oxybate • Inability to follow the instructions on the study procedures due to language problems, mental disorders, dementia, etc. • Presence of comorbid diseases that make sleep deprivation impossible (e.g. epilepsy) • Evidence of accidentally found epilepsy-typical potentials in the baseline night investigation that make sleep deprivation impossible • The following diseases/conditions considered to cause hypersomnolence and SOREMs on clinical grounds: o Other neurological disorders (e.g. stroke, multiple sclerosis, Parkinson's disease, severe traumatic brain injury, epilepsy) o Unstable psychiatric disorders (including acute psychoses, acute suicidality, severe depression, drug abuse) o Active infectious disease (e.g. encephalitis)

Design outcomes

Primary

Measure	Time frame
The aim of the study is to gain new insights into the clinical picture of narcolepsy and other diseases from the group of central hypersomnolence (narcolepsy, idiopathic hypersomnia, non-organic hypersomnia, chronic sleep deficiency syndrome, sleep apnea). The study can improve the diagnosis and classification of these diseases. New objective measurements are to be obtained that will enable simpler, faster and more precise diagnosis. New treatment options for drugs may also be derived from this.	—

Measure

Time frame

The aim of the study is to gain new insights into the clinical picture of narcolepsy and other diseases from the group of central hypersomnolence (narcolepsy, idiopathic hypersomnia, non-organic hypersomnia, chronic sleep deficiency syndrome, sleep apnea). The study can improve the diagnosis and classification of these diseases. New objective measurements are to be obtained that will enable simpler, faster and more precise diagnosis. New treatment options for drugs may also be derived from this.

—

Countries

Switzerland

Contacts

Public ContactRamin Khatami

Klinik Barmelweid

ramin.khatami@barmelweid.ch+41 62 857 22 22

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026