C34
Conditions
Interventions
Group 1: Lung cancer patients
Group 2: Control patients without lung cancer but other benign lung diseases and indication for thorax chirurgie
Group 3: Smokers without lung cancer
Group 4: Healthy c
Sponsors
Molekulare PneumologieUniversitätsklinikum Erlangen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Lung tumor patients and control patients with indication for VATS: Male and female patients 18 years of age and older with a diagnosis of lung cancer who meet the following additional criteria during clinical intervention will be included: -Completion of a thoracoscopic-guided (VATS = video-assisted thoracic surgery) or open surgical procedure on the lung; and -performance of a blood sampling procedure and/or -performing an ultrasound-guided, percutaneous diagnostic or therapeutic puncture of the pleural cavity (effusion, empyema) or a pleural mass and/or -performance of a bronchoscopy using a flexible or rigid technique (with endobronchial ultrasound: EBUS, if necessary) and/or -Performing a bronchoscopy with bronchial lavage. Healthy controls: -Healthy adults with no past or current tumor diagnosis. -Non-smokers Smoker controls: -Healthy adults with no past or current tumor diagnosis. -Regular tobacco consumption for at least 1 year.
Exclusion criteria
Exclusion criteria: Lung tumor patients and control patients with indications for VATS: -Autoimmune diseases -Severe chron. Diseases -Other cancer types Healthy controls and smokers: -Autoimmune diseases -Severe chron. Diseases -Malignant diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Collection of lung tissue, BAL and blood samples. Collection of immunological parameters by flow cytometry, cell culture, ELISA and RNA analysis. Survey of epidemiological parameters by questionnaires. | — |
Countries
Germany
Contacts
Public ContactSusetta Finotto
Molekulare PneumologieUniversitätsklinikum Erlangen
Outcome results
None listed