M62.5-
Conditions
Interventions
Group 1: sarcopenic older adults (65+)
Group 2: non-sarcopenic older adults (65+)
Group 3: younger adults (18-30)
Sponsors
Department for Geriatric Medicine, General Hospital Nuremberg, Paracelsus Private Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Geriatric patients aged = 65 years who are admitted to the geriatric day clinic - Participants in early and middle adulthood (18-30) - Consent of the patient
Exclusion criteria
Exclusion criteria: - lack of consent or lack of ability to give consent, including patients with delirium - Patients with other muscle diseases, paraparesis/paraplegia, or advanced coxarthrosis or gonarthrosis that prevent leg extension - Patients with known terminal disease with an expected lifetime 5 mg prednisolone / day - Use of statins in the last 3 years - Patients with cachexia, anorexia, obesity permagna, severe depressive illness, chronic rheumatological and chronic inflammatory diseases including malignant diseases. - patients with advanced immobility or bed confinement status - Participants in early adulthood (18-30 years) suffering from chronic rheumatological and chronic inflammatory diseases including malignant diseases, metabolic diseases, mental diseases, alcohol and drug abuse, as well as diseases of the central or peripheral nervous system. - Participants in early adulthood (18-30 years), who take medication regularly
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle stiffness of the rectus femoris muscle in rest position measured by shear wave elastography and presented in kilopascals (kPa). | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle stiffness of the rectus femoris muscle passively stretched, measured by shear wave elastography and expressed in kilopascals (kPa). Intraclass correlation (ICC) between experienced and inexperienced examiner Assessment of diagnostic performance compared to diagnostic gold standards including sensitivity, specificity, positive and negative predictive values as well as ROC curve analysis. Quantitative ultrasound muscle parameters or muscle thickness, muscle cross-sectional area and pennation angle | — |
Countries
Germany
Contacts
Public ContactMarkus Gosch
Department for Geriatric Medicine, General Hospital Nuremberg, Paracelsus Private Medical University
Outcome results
None listed