D48.1 Q85.8
Conditions
Interventions
Group 1: Pediatric patients diagnosed with VHL disease and available MRI examinations of the CNS during the period 01/2000 - 07/2022
Sponsors
Universitätsklinikum Freiburg
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: Pediatric patients diagnosed with VHL disease and available MRI examinations of the CNS during the period 01/2000 - 07/2022
Exclusion criteria
Exclusion criteria: Presence of sporadic CNS hemangioblastoma (thus excluding VHL disease). Presence of MRI examinations exclusively in adulthood.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical neurological status (modified Rankin Scale and modified McCormick Scale) of VHL patients at entry into adulthood in terms of the number of a) detected CNS hemangioblastomas as well as b) microsurgical removals of CNS hemangioblastomas in childhood/adolescence. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Comparison of clinical neurological status (mRS and modified McCormick Scale) postoperatively to preoperatively - Survey of complications and reasons of possible worsening of clinical outcome due to microsurgical therapy of CNS hemangioblastomas - To evaluate the indication for microsurgical removal of CNS hemangioblastomas in children/adolescents (asymptomatic/symptomatic) - Survey of clinical neurological symptoms that led to MRI examination of the CNS outside the screening intervals (unscheduled) - Survey of the number of tumor recurrences in childhood/adolescence - Age distribution of performed surgeries on CNS hemangioblastomas in VHL patients in childhood/adolescence - Survey of the number and distribution of CNS hemangioblastomas at the time of first MRI examination of the CNS - To survey the age in childhood/adolescence with first detection of CNS hemangioblastoma | — |
Countries
Germany
Contacts
Public ContactJan-Helge Klingler
Universitätsklinikum Freiburg, Klinik für Neurochirurgie
Outcome results
None listed