Network-based functional neuroimaging in cognitive sequelae after concussive brain injury and cognitive training

Network-based functional neuroimaging in cognitive sequelae after concussive brain injury and cognitive training - KogNet-CBI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029388

Enrollment

Registered

2022-08-09

Start date

2023-01-15

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

F07.2

Interventions

Group 1: Early Intervention: 4 weeks of digital cognitive Training - NEUROvitalis digital ( Baller et al. 2009) - with five sessions per week à 30 minutes with in the early phase 4 weeks after trauma

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: - Medically diagnosed concusion within last 3 weeks - Deficit in attention and/or memory as well as at least two symptoms as defined by Post-Concussion Syndrome (e.g. headache, numbness, fatigue, irritability, insomnia, noise/light sensitivity). - Objectifiable cognitive deficit in terms of at least below average cognitive performance (reduction of the total value of the CogBat (Aschenbrenner et al., 2012) by more than one standard deviation below age-corrected norm) - Age 18-65 years

Exclusion criteria

Exclusion criteria: - Severe psychiatric or neurological desease in the past - Frequent use of central operating medicine or drugs - Lacking capacity to consent - Deficient knowledge of the german language to perform the intervention - Contraindication for MRI examination - Pacemaker, cochlea implant, vascular clip or other metal implant, stimulation device or drug pumps, metal splinters, tatoos - Nursing, pregnent and women by whom a pregnancy can’t be foreclosed - Claustrophobia

Design outcomes

Primary

Measure	Time frame
Total value of cognition, determined by the validated computerbased neuropsychological battery of tests. CogBat (Aschenbrenner, Kaiser, Pfüller, Roesch-Ely, & Weisbrod, 2012) after 4 respectively 16 weeks.	—

Secondary

Measure	Time frame
i. Change of functional networks based on global graph parameter (using fMRI resp. qEEG) ii. Total vale of Rivermead Post Concussion Questionaire (RPCQ) iii. Domain scores of attention, memory and executive functions determined by CogBat iv. Subjectively perceived mental performance determined by CogBat[Freitext] v. Nuisance through headache, fatigue resp. insomnia determined by Headache Impact Test-6 (HIT-6), Multidimensional Fatigue Inventory (MFI) resp. Insomnia Severity Index (ISI) vi. Serum level of neurofilament light chain (NFL)	—

Measure

Time frame

i. Change of functional networks based on global graph parameter (using fMRI resp. qEEG) ii. Total vale of Rivermead Post Concussion Questionaire (RPCQ) iii. Domain scores of attention, memory and executive functions determined by CogBat iv. Subjectively perceived mental performance determined by CogBat[Freitext] v. Nuisance through headache, fatigue resp. insomnia determined by Headache Impact Test-6 (HIT-6), Multidimensional Fatigue Inventory (MFI) resp. Insomnia Severity Index (ISI) vi. Serum level of neurofilament light chain (NFL)

—

Countries

Germany

Contacts

Public ContactStefan Blaschke

Uniklinik KölnKlinik für Neurlogie

stefan.blaschke@uk-koeln.de022147842699

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026