Basic science study investigating stress effects on behavioral and neural correlates of memory processes with potential implications for stress-associated disorders such as PTSD and depression.
Conditions
Interventions
Group 1: Control group: placebo
Group 2: 1. experimental group: 20mg yohimbine
Group 3: 2. experimental group: 20mg hydrocortisone
Sponsors
Universitätsklinikum Eppendorf - Sonderforschungsbereich 936 - Multi-Site Communication in the Brain
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: - very good knowledge of German - Right-handed
Exclusion criteria
Exclusion criteria: - Pregnancy - Psychology studies - smoker - hormonal contraceptives (e.g. pill, ring, patches etc.) - metal on/in the body (e.g. stents, copper coil, piercings that cannot be removed) - acute illnesses and/or medication - history of neurological or mental disorders - participated in a study in the last 2 months in which active substances had to be taken
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Knowledge of the influence of stress on reconsolidation and related changes in neural correlates. | — |
Primary
| Measure | Time frame |
|---|---|
| To investigate the influence of physiological stress mediators after memory reactivation on memory performance as well as the brain processes involved in it 24 h later. Memory performance will be assessed on the third day of the study, 24 h after the pharmacological intervention, using computerized tests. In these tests, old words (learned on day 1) and new words are presented. Subjects must first indicate whether the word shown is old or new, and then indicate which picture belongs to that word. | — |
Countries
Germany
Contacts
Public ContactHendrik Heinbockel
Universität Hamburg
Outcome results
None listed