F32 F31
Conditions
Interventions
Group 1: Patients with depression will each be examined at the time point with high symptom burden and a time point with low symptom burden. The following parameters will be collected: Questionnaires,
Sponsors
Goethe Universität Frankfurt
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with depression: Age: between 18 and 75 years Presence of depressive disorder without psychotic symptoms (according to ICD 10: F32.0, F32.1, F32.2, F32.3, F33.2, F33.3) or bipolar affective disorder with depressive episode (ICD: F31.3, F31.4) Capacity to consent Patients with MS: Inclusion criteria for patients* with MS: o Age between 18 and 75 o Capacity to consent o If applicable, the last cortisone treatment has taken place at least 7 days ago. occurred Controls:Inclusion criteria for healthy controls: Age: between 18 and 75 years Capacity to consent
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with depression: Presence of severe neurological disease, such as multiple sclerosis. (adjusted epilepsy is allowed) Presence of an acute infection (pneumonia, urinary tract infection, sepsis) Clearly organic or substance-induced cause of depression Pregnancy and lactation Psychiatric comorbidities are allowed as long as, in the opinion of the study physician there is no impairment at testing and will be documented Other medical condition that, at the discretion of the physician, makes participation impossible. Uncontrolled thyroid disease (thyroid disease must be anamnestically stable, i.e., no change in medication has been made in the last 28 days). Exclusion criteria for patients with MS: Acute infection (per history) or tumor. Uncontrolled thyroid disease (thyroid disease must be anamnestically stable, i.e., no change in medication has been made in the last 28 days). Exclusion criteria for healthy controls: Presence of psychiatric illness or psychiatric illness in First-degree family members Severe physical illness (tumor disease, chronic/acute infectious disease, neurodegenerative disease, rheumatological disease, severe inflammation, autoimmune diseases, neurological disease) Pregnancy and lactation Uncontrolled thyroid disease (thyroid disease must be anamnestically stable, i.e., no change in medication has been made in the last 28 days).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The aim of the study is to establish symptom profiles based on biological and psychological factors that are variably associated with symptom burden | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessing stress reactivity in depression; Assessing the effect of short chain fatty acids on immune cell subsets | — |
Countries
Germany
Contacts
Public ContactCarmen Schiweck
Goethe Universität Frankfurt
Outcome results
None listed