Sacral distribution pattern of bone mass and fat marrow by quantitative CT- and MRI-analysis considering bone mineral density

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029319

Enrollment

Registered

2022-07-12

Start date

2021-11-30

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

M81.90 S32.1

Interventions

Group 1: Retrospective evaluation of CT- and MRI-examinations of the pelvis with regard to the distribution pattern of bone mass and fat marrow content in the transsacral corridors S1 to S3 of 14 pati

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: - all groups: CT and MRI (including mDixon quant – sequence) of the pelvis - PaInNo: intact pelvises, no osteoporosis - PaInO: intact pelvises, osteoporosis - PaFrO: unilateral fractures of the sacrum, osteoporosis

Exclusion criteria

Exclusion criteria: - all groups: missing mDixon quant –sequence, implants oder metastasis in the pelvis - PaInNo: fractures of the sacrum, osteoporosis - PaInO: fractures of the sacrum, no osteoporosis - PaFrO: no/bilateral/transverse fractures of the sacrum, no osteoporosis

Design outcomes

Primary

Measure	Time frame
Description of the zonal differences in bone mass and fat marrow content in the sacrum between bone-healthy and osteoporotic pelvises and a bilateral comparison in unilaterally fractured sacra. Determination of the relationship between bone mass and fat marrow with regard to the distribution pattern along the transsacral corridors. Measurement parameter of the bone mass is the CT value (in Hounsfield units) and of the fat marrow content is the FatFraction (in %), which is measured in the FatFraction-Map of the mDixon quant sequence. Assessment of bone mineral density using the qCT (for PaFrO) and the CT value measurement in LWK 5 (for PaInNo and PaInO).	—

Measure

Time frame

Description of the zonal differences in bone mass and fat marrow content in the sacrum between bone-healthy and osteoporotic pelvises and a bilateral comparison in unilaterally fractured sacra. Determination of the relationship between bone mass and fat marrow with regard to the distribution pattern along the transsacral corridors. Measurement parameter of the bone mass is the CT value (in Hounsfield units) and of the fat marrow content is the FatFraction (in %), which is measured in the FatFraction-Map of the mDixon quant sequence. Assessment of bone mineral density using the qCT (for PaFrO) and the CT value measurement in LWK 5 (for PaInNo and PaInO).

—

Secondary

Measure	Time frame
Improvement of the understanding of the typical fracture course of fragility fractures of the sacrum as well as determination of optimal locations for screw fixation in osteoporotic bone structure. Investigation of the hypothesis that reduced bone structure is replaced by fat in osteoporosis.	—

Countries

Germany

Contacts

Public ContactThomas Mendel

BG Klinikum BergmannstrostKlinik für Unfall- und Wiederherstellungschirurgie

thomas.mendel@bergmannstrost.de0049 +345 132 6632

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026