F00.1
Conditions
Interventions
Group 1: In the current study, patients participate in two runs of a memory paradigm, one with active deep brain stimulation (Stim-ON) and one with stimulation switched off (Stim-OFF). Besides behavio
Sponsors
Universitätsklinikum Köln
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: • DBS with continued stimulation • Capacity to consent • Written declaration of consent from the patient
Exclusion criteria
Exclusion criteria: • Placement in an institution by court and official order (according to § 20 MPG) • Lack of cooperation • Movement disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| memory performance in both runs (Stim-ON vs. Stim-OFF; number of correct items, localization). We use an established paradigm for episodic and spatial context memory with two available sets of stimuli (Muecke et al, 2018). The number of correctly recognized items (z(hit)-z(false alarm)) and the localization of the items (distance between the dragged position and the correct position on the screen) in an immediate and a delayed recall are evaluated. | — |
Secondary
| Measure | Time frame |
|---|---|
| - EEG power - EEG coherence - HRV, EDA, pupil width - correlation between behavioral data and volume of tissue activated - functional and structural connectivity analyses based in sweet spot | — |
Countries
Germany
Contacts
Public ContactÖzgür Onur
Klinik und Poliklinik für Neurologie Uniklinik Köln
Outcome results
None listed