ARDS
Conditions
Interventions
Group 1: Intervention:
Lowering the core body temperature to 34°C
Intervention period:
48h from reaching the target temperature
Sponsors
Charité Campus Virchow-Klinikum
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: - Age >18 years - Intensive medical therapy with invasive mechanical ventilation of any indication - VV-ECMO with blood flow > 5l/min - Persistent hypoxia (pO² 6h) with optimal ventilation and VV ECMO therapy - Deep analgosedation (RASS -5)
Exclusion criteria
Exclusion criteria: - Severe intra-abdominal, thoracic, gastrointestinal and/or intracerebral bleeding - Hemophilia/severe thrombocytopenia (<20) - Coagulation failure (Quick < 50) - septic/cardiogenic shock - Severe circulatory instability - Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygen saturation and oxygen partial pressure (pO2) before, during and after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Gas exchange: - Blood gas analyses (BGA) (no additional samples are planned as part of the study, as BGAS is routinely performed every 2-4 hours in VV-ECMO patients) - Blood and gas flow at the VV-ECMO - Duration of ventilation - Duration of ECMO therapy Hemodynamics: - Heart rate - Documentation of any rhythm abnormalities - Blood pressure analysis (sys / dias / MAD) - Catecholamine supplies Laboratory findings: - Infection values - Liver, heart and kidney function - VEGF as a hypoxia marker - kidney values - Blood count - Coagulation - Electrolyte balance Other: - mortality (30 days or until discharge from the intensive care unit), | — |
Countries
Germany
Contacts
Public ContactJulius Kunz
Klinik für Nephrologie und IntensivmedizinCampus Charité MitteCharité - Universitätsmedizin Berlin
Outcome results
None listed