pain perception healthy participants
Conditions
Interventions
Group 1: healthy subjects to receive heat pain stimuli in all 3 experimental conditions (within-subject design)
Sponsors
Universitätsklinikum EssenKlinik für Neurologie
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Age: 18-40 years, consent to study, fluent German skills, healthy
Exclusion criteria
Exclusion criteria: Alcohol consumption one day before trial day 2 and/or 3; Alcohol consumption on trial day 1-3; Substance/drug use in the last 4 weeks; Medication use in the last 7 days (except hormonal contraceptives); Use of anticoagulant or pain medications in the last 24 hours; Known neurological, internal, psychological, as well as skin and cold-associated diseases; Allergies (contact allergies); Participation in an electrostimulation or heat stimulation study in the last 6 months; Color blindness or red-green deficiency; Surgical procedures in the last 6 months; Injuries/scars on the forearms; Skin damage (e.g. sunburn) on the forearms; Limited visual acuity or uncorrected visual acuity; Restricted hearing; Acute infections
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The extent of placebo analgesia and nocebo hyperalgesia (difference in subjective pain intensity as an interaction between the experimental condition (placebo vs. nocebo vs. control) on the day of the conditioning phase. | — |
Secondary
| Measure | Time frame |
|---|---|
| The extent of placebo analgesia and nocebo hyperalgesia one week after the conditioning phase; The expectation of pain intensity on the day of conditioning and one week later compared to baseline (before conditioning); Exploratory outcome measures are treatment experience and tolerability, genetic predispositions (saliva sample), tolerability and side effects on day 1, 2 and 8 (GASE), psychometric predictors (prior experience with placebo treatment, somatosensory amplification (Somatosensory Amplification Scale, SSAS), perceived stress (Perceived Stress Scale, PSS), Anxiety and depression as a state (State)/current state (State-Trait-Anxiety-Depression Inventory, STADI State), Anxiety and depression as a trait (Trait)/general state anxiety and depression (STADI Trait), Fear of pain (Fear of Pain Questionnaire-III (FPQ-III)), Catastrophizing thoughts related to pain (Pain Catastrophizing Scale, PCS), Personality factors (10-item Big Five Inventory)). | — |
Countries
Germany
Contacts
Public ContactAngelika Kunkel
Universitätsklinikum EssenKlinik für Neurologie
Outcome results
None listed