Healthy volunteers
Conditions
Interventions
Group 1: Caffeine Shampoo No.1 (Verum).
72 mg of the caffeine-containing shampoo formulation is massaged into an area of 6 cm x 6 cm with the index finger over a period of 2 min. The formulation is t
Sponsors
The Procter & Gamble Company, Mason Business Center
Eligibility
Sex/Gender
Male
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: The studies will be conducted on study participants who are -> 18 years to 60 years old and have no skin diseases - have given written informed consent - have a skin type of I-III (Fitzpatrick) - have been informed about the aims of the study and the nature of the examinations
Exclusion criteria
Exclusion criteria: - Minors - persons who have tattoos in the area of the calves - known skin diseases - skin type >III (Fitzpatrick) - persons who cannot make decisions on their own responsibility
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is the caffeine content in hair follicles [nmol/L]. To obtain this, a cyanoacrylate tapestrip of the skin is made, which is then dissolved in ethanol. The extract thus obtained in ethanol is then determined by mass spectrometry (via LC-MS/MS) with regard to its caffeine content. | — |
Secondary
| Measure | Time frame |
|---|---|
| The primary endpoint is the caffeine content in the stratum corneum [nmol/L]. To obtain this, 50 tapestrips of the skin are made, which then are dissolved in ethanol. The extract thus obtained in ethanol is then determined by mass spectrometry (via LC-MS/MS) with regard to its caffeine content. | — |
Countries
Germany
Contacts
Public ContactHeike Richter
Charité - Universitätsmedizin Berlin, Klinik für Dermatologie, Venerologie und Allergologie
Outcome results
None listed