F20 F21 F22 F23 F24 F25 F28 F29
Conditions
Interventions
Group 1: High-Intensity-Training
In addition to the standard therapy concept, a machine-supported strength and endurance training of approx. 30 minutes is performed three times a week. The training c
Sponsors
Universitätsklinikum Köln
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Individuals may participate if they have a diagnosed paranoid psychosis (F20-F29), are between 18 and 60 years of age, and give written informed consent to participate in the study.
Exclusion criteria
Exclusion criteria: - Pre-existing conditions of the heart or lungs, - uncontrolled diabetes mellitus, - pre-existing diseases affecting the immune system ("autoimmune diseases", e.g. Hashimoto-Thyroiditis, Crohn's disease, ulcerative colitis, etc.), Thyroiditis, Crohn's disease, ulcerative colitis, etc.), - rheumatological pre-existing diseases (e.g. "rheumatism", arthritis, ankylosing spondylitis, etc.) - acute thromboses, - implants in the trained body regions (e.g. artificial joints, partial prostheses), - metal implants in the head region (e.g. deep brain stimulator, fixed braces) - Acute inflammation of muscles, tendons or joints, - chronic infectious diseases (e.g. HIV, hepatitis) - cardiac pacemaker, - an acute back problem (e.g. herniated disc), - fresh bone fractures in the trained body regions, - stone disease of bile ducts and urinary tract, - severe head injuries or operations (acute or ever), - diseases affecting the muscles, joints or bones, - diseases that may affect the brain (e.g. epilepsy, multiple sclerosis), - addictive diseases, - current pregnancy - lack of German language skills - an IQ below 70 - taking medication that can affect the function of the heart (e.g. beta-blockers)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pre and post: psychiatric symptoms (PANSS questionnaire), cardio-respiratory fitness VO2peak (spiroergometry) and maximum strength (one repetition maximum) | — |
Secondary
| Measure | Time frame |
|---|---|
| pre and post functioning and depression (GAF and BDI questionnaires), hippocampal volume (MRI), neuropsychological testing, blood infection markers (CRP, IL-6, BDNF, TNF-alpha, GSH), heart rate variability, motivational task | — |
Countries
Germany
Contacts
Public ContactMatthias Rißmayer
Uniklinik Köln: Klinik und Poliklinik für Psychiatrie und Psychotherapie
Outcome results
None listed