J95.88
Conditions
Interventions
Group 1: For one group (intervention group), the Venner PneuX™ tube system with subglottic suctioning will be used. The observation will take place over a ventilation period of 4-5 days.
As part of a
Sponsors
Universitätsklinikum Heidelberg Klinik für Anästhesiologie
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: All patients requiring intubation and ventilation due to acute respiratory failure in the Surgical Clinic of Heidelberg University Hospital during the study period will be included. A total of 50 patients will be included in the study. Inclusion will be in chronological order. The following criteria must be met: Acute respiratory failure Need for airway protection by a tube for invasive ventilation Age >18 years Written informed consent by legally appointed representative.
Exclusion criteria
Exclusion criteria: Exclusion criteria are defined as: Refusal to participate in the study Pregnancy Age <18 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Study of the changes in the pulmonary microbiome. Study of the changes of the microbiome in correlation with clinically relevant complications. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the prognostic value of microbiome analysis. Correlation between pathogen diagnostics via NGS (next generation sequencing) and culture based. Investigation of changes in pulmonary immune cells. Investigation of changes in the pulmonary metabolome. Investigation of a possible correlation between patient immune status, microbiome and metabolome. Outecomeevaluation after 28 days. | — |
Countries
Germany
Contacts
Public ContactMascha O. Fiedler-Kalenka
Universitätsklinikum Heidelberg Klinik für Anästhesiologie
Outcome results
None listed