Impact of a protein-based restriction diet enriched with rapeseed oil on nutrient sensors and immunomodulators in the stomach of severely obese patients (obesity permagna)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

DRKS

Registry ID

DRKS00029161

Enrollment

Registered

2022-05-30

Start date

2022-07-01

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Group 1: control group (group A): four weeks of low calorie, low carb, protein-rich dieet (3x 20 g protein powder (80 g protein per 100 g powder/day)) Group 2: treatment group (group B). four weeks of

30 ml rapeseed oil (= 2.7 g alpha-linolenic acid)

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: free, written consent; age 18-65; BMI > or equal 50, laparoscopic sleeve gastrectomy, < 5 kg change in body weight within previous 2 months

Exclusion criteria

Exclusion criteria: not capable of consent, type II diabetes (Hba1c>6,5), inherited dyslipidemias, Helicobacter pylori infection, CKD (creatinine > 1,2 mg/dl), IBD, other intestinal disorders, food intolerance or allergy (milk, soy, pea) vegetarian, alternative diet plans, therapy with steroids or antibiotics (less than 2 months before or during the study), gastrointestinal infections (less than 2 months before or during the study)

Design outcomes

Primary

Measure	Time frame
percentage of ghrelin-positive cells in the mucosa of the stomach after dietary intervention	—

Secondary

Measure	Time frame
plasma acyl-ghrelin level	—

Countries

Germany

Contacts

Public ContactTobias Meile

Krankenhaus Bad CannstattAdipositas-Zentrum

t.meile@klinikum-stuttgart.de071127862667

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Jun 11, 2026