N18
Conditions
Interventions
Group 1: Uptake of cholecalciferol after a single oral administration
Sponsors
Universitätsklinikum der RWTH Aachen
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: • stable, chronic hemodialysis patients • Age of = 18 years • Written informed consent prior to study participation • The subject is willing and able to follow the procedures outlined in the protocol Control group: • Normal renal function • Age- and sex-matched as well as written informed consent prior to study participation • The subject is willing and able to follow the procedures outlined in the protocol
Exclusion criteria
Exclusion criteria: • Age less than 18 years • Severe medical events within the last month • Planned surgery within the duration of the sampling • Acute/chronic gastrointestinal infections • Recent or ongoing antibiotic therapy • Conditions that impair vitamin D uptake or metabolism (chronic inflammatory bowel disease) • Severe dyslipidemia • Severe anemia, defined as hemoglobin level less than 9.0 g/dl • Pregnant and lactating females • Committed to an institution by legal or regulatory order • Participation in a parallel interventional clinical trial • Receipt of an investigational drug within 30 days prior to inclusion into this study • The subject is mentally or legally incapacitated • Vitamin D supplementation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Determination of vitamin D content in lipoproteins up to 96h after ingestion | — |
Countries
Germany
Contacts
Public ContactNadine Kaesler
Universitätsklinik der RWTH AachenMedizinische Klinik II
Outcome results
None listed