Family transmission of SARS-CoV-2 (COVID-19) of children and adolescents following household exposure with analysis of humoral, cellular and mucosal immunity

Family transmission of SARS-CoV-2 (COVID-19) of children and adolescents following household exposure with analysis of humoral, cellular and mucosal immunity - OMI-Kids

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029155

Enrollment

250

Registered

2023-05-11

Start date

2022-03-31

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

SARS-CoV-2 COVID-19

Interventions

Group 1: household member with PCR-proven SARS-CoV-2 infection working as index for all other included household members (e.g. corresponding to our website: PCR-testing of all members of the household

Eligibility

Sex/Gender

All

Age

1 Years to 99 Years

Inclusion criteria

Inclusion criteria: - all children and adult household members, minimum age 1 year - informed consent of all family members - PCR-proven SARS-CoV-2 infection of one household member, maximum 72h before inclusion - permanent address in Baden Wuerttemberg, Germany

Exclusion criteria

Exclusion criteria: - insufficient German language skills (ICs in German) - family living in more than one apartment (e.g. separated parents) - severe congenital diseases - immunosuppression

Design outcomes

Primary

Measure	Time frame
Secondary attack rate (SAR) following household exposure	—

Secondary

Measure	Time frame
1. clinical manifestation of infection 2. SARS-CoV-2 specific humoral immune response 3. SARS-CoV-2 specificmucosal immune response 4. SARS-CoV-2 specific T-cell immune response	—

Countries

Germany

Contacts

Public ContactRoland Elling

Zentrum für Kinder- und JugendmedizinUNIVERSITÄTSKLINIKUM FREIBURGAbteilung Pädiatrische Infektiologie und Rheumatologie

roland.elling@uniklinik-freiburg.de+49 (0)761 270 43000

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 4, 2026