Non-antibiotic prophylaxis for recurrent UTIs in neurogenic lower urinary tract dysfunction

Non-antibiotic prophylaxis for recurrent UTIs in neurogenic lower urinary tract dysfunction - NAPRUN

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

DRKS

Registry ID

DRKS00029142

Enrollment

785

Registered

2022-06-07

Start date

2023-10-01

Completion date

Unknown

Last updated

2025-04-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

N31

Interventions

Group 1: UroVaxom (OM-89) will be administered as a standard regimen: once daily for three months with a three month pause following and three ten-day cycles at 7, 8 and 9 months. Group 2: StroVac (ba

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: ? Microbiologically proven UTI ? Age>18 ? Ability to consent ? NLUTD with practised ISC ? rUTI (used definition: more than 3 infections per year or two infections within 6 months) ? Non-antibiotic prophylaxis with UroVaxom, StroVac, Angocin, D-Mannose or bladder irrigation with saline ? Signed informed consent form

Exclusion criteria

Exclusion criteria: ? Patients practicing ISC with augmented bladder or continent pouches ? Inability to consent ? Intention-to-treat analysis for dropouts

Design outcomes

Primary

Measure	Time frame
Number of breakthrough infections	—

Secondary

Measure	Time frame
Adverse events associated with the prophylaxis regimens and severity of breakthrough infections.	—

Countries

Germany, Switzerland

Contacts

Public ContactLaila Schneidewind

Universitätsmedizin RostockUrologische Klinik und Poliklinik

laila.schneidewind@med.uni-rostock.de+49 381 494 7801

Outcome results

None listed

Source: DRKS (via WHO ICTRP) · Data processed: Feb 9, 2026