Mast cell activation syndrome (MCAS
Conditions
Interventions
Group 1: Patients with a diagnosis of mast cell activation disease (MCAD): A one-time quantitative sensory testing (QST) assessment will be performed, together with the collection of clinical and life
Sponsors
Universitätsklinikum Bonn
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: • Confirmed diagnosis of a mast cell activation disease (MCAD): - Mastocytosis according to the World Health Organization (WHO) diagnostic criteria - Mast cell activation syndrome (MCAS) according to the diagnostic criteria proposed by Afrin, Molderings et al. (2020) • Prior provision of study information and written informed consent
Exclusion criteria
Exclusion criteria: • Inability to provide written informed consent • Inability to follow the verbal instructions required for quantitative sensory testing (QST) • Regular use of analgesics, psychotropic medication, or other medications that may affect pain perception within the previous 4 weeks • Contraindications to quantitative sensory testing (QST): skin and soft tissue disorders, pregnancy, or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in somatosensory profiles between patients with mast cell activation disease (MCAD) and healthy controls, assessed by a single quantitative sensory testing (QST) procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Association between individual quantitative sensory testing (QST) parameters and clinical characteristics and medical history of patients, as assessed by questionnaire. | — |
Countries
Germany
Contacts
Public ContactRumeysa Polat
Universitätsklinikum Bonn
Outcome results
None listed